Studies on the Development of Carbon Monoxide-Releasing Molecules: Potential Applications for the Treatment of Cardiovascular Dysfunction

I. Introduction ...............................................................................................250 II. Generation of Carbon Monoxide in the Cardiovascular System..............251

III. Carbon Monoxide in the Heart: Role of Heme Oxygenase in the Mitigation of Myocardial Ischemia/Reperfusion Injury ...........................256

IV. Use of Transition Metal Carbonyls as Carbon Monoxide-Releasing Molecules ................................................................260 A. Chemistry of Transition Metal Carbonyls ........................................260 B. Detection of CO from CO-RMs .......................................................261 C. Biological Activity of CO-RMs........................................................262