chapter  2
22 Pages

Carbon Monoxide-Induced Vasorelaxation and the Underlying Mechanisms

I. Overview of the Vascular Effects of CO ....................................................24 II. The Effects of CO on Different Cellular Components

of Vascular Walls .........................................................................................26 A. Effect of CO on Cultured Vascular Smooth Muscle Cells.................26 B. The Role of Endothelium in the Metabolism and Function

of CO...................................................................................................27 1. Expression of HO Isoforms and Production of CO in

Endothelial Cells ...........................................................................27 2. Mediation of Vascular Effect of CO by Endothelial Cells...........28 3. Regulation of Non-Contractile Functions of Vascular

Tissues by Endothelium-Derived CO ...........................................29 C. Effect of CO on Nerve Terminals and Neurotransmitters

within Vascular Walls ..........................................................................29 III. The Vasorelaxant Effects of Endogenous CO.............................................30