chapter  35
26 Pages

In Vivo and In Vitro Near-Infrared Spectroscopic Determination of Blood Glucose and Other Biomedical Components with Chemometrics

WithYi Ping Du, Sumaporn Kasemsumran, Jian-Hui Jiang, Yukihiro Ozaki

Spectroscopy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 686 35.4 Region Orthogonal Signal Correction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 689

35.4.1 Orthogonal Signal Correction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 690 35.4.2 Region Orthogonal Signal Correction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 691

35.5 Removal of Interference Signals Due to Water from In Vivo NIR Spectra of Blood Glucose by ROSC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 692 35.5.1 Spectra Pretreated by OSC and ROSC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 693 35.5.2 Comparison of Prediction Ability between Models Developed by Using

OSC-and ROSC-Pretreated Spectra. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 694 35.5.3 Selection of Spectral Regions to Improve PLS Model Performance . . . . . . . . . . . . . . 694

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 697

DBURNS: “7393_c035” — 2007/7/23 — 21:56 — page 674 — #2

In vivo and in vitro near-infrared (NIR) spectroscopic determination of blood glucose and other biomedical components with chemometrics have received keen interest because it is a noninvasive analytical technique with no or little pretreatment [1-37]. Particularly, in vivo blood glucose measurement has been a matter of great importance since the demand for the noninvasive blood glucose assays has been growing due to the worldwide increase in the number of diabetics [22-26,28,33-37]. The noninvasive blood glucose measurements by NIR spectroscopy may open the possible use for clinical diagnosis, examination for diabetes at a hospital or a house, and have glucose monitoring devices.