Chiral Separation of β-Adrenergic Antagonists
Drugs affecting adrenergic receptors as antagonists are mostly used in the treatment of different cardiovascular diseases, for example, hypertension, angina pectoris, cardiac arrhythmias, and glaucoma. The group of drugs targeting β-adrenergic receptors as antagonists (β-blockers) exhibit a high stereoselectivity in provoking their β-blocking effects. Chiral separations of different β-blockers have been performed using direct and indirect modes. Molecular imprinting is a technique for the preparation of “tailor-made” selectors, which are used for the separation of numerous classes of both achiral and chiral compounds. The chiral recognition of benzoate and phenylcarbamate cellulose derivatives greatly depends on the type and position of the substituents introduced into the phenyl group. The formation of diastereomeric ion pairs using chiral-ion interaction agents represents the basis for the resolution of enantiomers. Dissimilar distribution properties of the formed diastereomers enable their discrimination on nonchiral stationary phases.