chapter  8
24 Pages

Dereplication and Discovery of Natural Products by UV Spectroscopy

WithThomas O. Larsen and Michael A.E. Hansen

A major challenge in the discovery of natural products is to implement a good strategy for rapid detection of previously isolated compounds. This dereplication process is to ensure that isolation, structure elucidation, and pharmacological investigations can be focused on novel compounds.1 In this scenario, chromatography combined with high-resolution mass spectrometry,2 diode array detection (DAD) of UV/Vis absorbance, or nuclear magnetic resonance (NMR) spectroscopy3-5

plays an important role. The data generated from these techniques are then often combined with searching of databases such as Chemical Abstracts Service using SciFinder,6 Antibase,7 or MarinLit.8