chapter  1
58 Pages

Drug-Induced Hepatic Disease

ByHyman J. Zimmerman

Individual susceptibility to hepatic injury may be affected by genetic factors, age, sex, nutritional status, exposure to other drugs and chemicals, systemic disease, and other factors (Table 1 ). For the most part, the factors that affect vulnerability appear to result from their effects on conversion of the respective agents to a metabolite or on the detoxification or disposal of the metabolite (5).