ABSTRACT
Airway remodeling in asthma was originally observed in fatal cases (1) but has been confirmed in other materials (2,3). An abnormal decline in FEVi with age has been found particularly important in nonallergic asthma (4). Clinical observations have indicated that not only airways but also lung parenchyma is remodeled in long-lasting asthma. Paganin et al. (5) showed with highresolution computed tomography that permanent abnormalities occur with re spect to both bronchi and parenchyma. They confirmed that the pathology is more pronounced in nonallergic asthma. Signs of fibrosis and peribronchial thickening were frequently observed. Emphysema was another common finding.
