ABSTRACT
Dermoelectroporation is a treatment method that enables absorption of active substances (normally they are ionic drug solutions) using equipment that generate electric pulses allowing the opening of cellular ‘‘electric gates’’ and promoting the passage of substances through the epidermis. In 1970, a group of American dermatologists discovered that by applying an intense electrical impulse for a short time at an adequate wave length, a change in polarization of the cellular membrane occurred, which could be used to promote a kind of cellular ‘‘pulsation.’’ In fact, after the initial pulse, the polarity is slowly reversed, avoiding electrolysis, and this opens intercellular channels through which substances can pass. Once they are formed, these channels stay open for a relatively long time-several seconds.
