chapter  12
20 Pages

Dementia in Parkinson’s Disease and Lewy Body Disorders

ByJames E. Galvin

Dementia is a major public health problem, crossing gender, socioeconomic, and ethnic lines. The

incidence of dementia increases with age and prevalence increases every decade after age 65 (1,2).

Alzheimer’s disease (AD), the most common cause of dementia, is covered in detail by Morris in

Chapter 10. The differential diagnosis of dementia includes a wide range of disorders, many of

which are covered by other authors in this volume. The focus of this chapter will be on disorders

where Lewy bodies (LBs) are the predominant distinctive pathology whether or not AD pathologic

lesions [senile plaques (SPs) and neurofibrillary tangles (NFTs)] are also found. In this chapter we

will review three disorders that share common clinical and cognitive features as well as

pathologic lesions.