chapter  25
20 Pages

Amyloid-Based Strategies to Treat and Prevent Alzheimer’s Disease

ByDennis J. Selkoe

Few experiences in the work of a neurological diagnostician are more dispiriting than informing

both patient and family that the diagnosis is Alzheimer’s disease (AD). Yet, with the remarkable

rise in life expectancy and the gradual decline in competing causes of late-life brain failure, this is a

diagnosis that clinicians are reaching with ever-increasing frequency. To change this scenario, we

must thoroughly understand the molecular underpinnings of this complex syndrome and devise

rational, mechanism-based agents for preventing it.