ABSTRACT
Current evidences have expended the concept that chronic inflammation might play a crucial role in the development and progression of several gastrointestinal cancers. For instance,many cancers originated fromgastrointestinal tissues are closely associated with chronic, persistent inflammation
presenting as chronic Helicobacter pylori-infected gastritis, inflammatory bowel disease, Barrett’s esophagus, and chronic viral hepatitis. Here, we discuss the molecular evidence that chronic inflammation is capable of inducing cancer and the procancermicroenvironment (PCM) favorable for survival of tumor cells and their growth. The explainable factors fostering the neoplastic process are including (1) the induction of neoplastic mutation by oxidative stress, (2) enhancement of cell proliferationandapoptosis inhibition, (3) theproductionofproteasesand growth factors providing the environment for cell migration, and (4) the induction of angiogenesis. Thus, this evidence has helped to shed light on anti-inflammatory treatment or antioxidants as promising protective therapeutic approach for cancer prevention.
