chapter  14
Taking Prognostic Signatures to the Clinic
ByMichail Ignatiadis, Christos Sotiriou
Pages 15

The advent of microarray technology and the sequencing of the human genome

have enabled scientists to simultaneously interrogate the expression of thousands

of genes. These gene expression profiling studies have provided (i) a molecular

classification of breast cancer into clinically relevant subtypes, (ii) new tools to

predict disease recurrence and response to different treatments, and (iii) novel

insight into various oncogenic pathways and the process of metastatic progression.