chapter  3
Role of Genetic Variability in Breast Cancer Treatment Outcomes
ByKandace L. Amend, Ji-Yeob Choi, Christine B. Ambrosone
Pages 19

Variability in toxicity and response to the same dose of medication may occur

among cancer patients and contribute to the unpredictability of clinical out-

comes. In addition to the potential importance of clinical factors in determining

drug effects (1), inherited differences in drug metabolism are likely to have a

profound effect on treatment outcomes (2). Pharmacogenetics, the study of the

contribution of genetic variation to these interindividual differences, may allow

for the individualization of therapy and improved prediction of pharmacody-

namic events, including host toxicity and treatment efficacy. To date, the role of

pharmacogenetics in breast cancer therapy has not been clearly defined. Herein

we discuss the drugs most commonly used to treat breast cancer and describe

their metabolic pathways, as well as provide epidemiologic support for the role

of pharmacogenetics in breast cancer outcomes.