Quantitative diuse reectance imaging (QDRI) is an emerging modality that collects and analyzes reectance spectra produced as ultraviolet-visible (UV-VIS) light propagated through a turbid medium to determine the absorption and scattering properties of the medium. From the absorption spectra, tissue composition maps, such as the concentrations of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb), can be extracted, while the scattering map reects the tissue morphological information, such as nuclear size and density. Both tissue compositions and morphological information have been identied as useful biomarkers for cancer diagnostics. QDRI has attracted growing interest for noninvasive tissue characterization in the last decade. One, and maybe the most important, application of this technology is for noninvasive detection of tumor margins during surgeries, such as breast-conserving surgery (BCS) and brain surgery, where maximal preservation of normal tissue or functionality is critical.