chapter  19
Interferometric Light Scattering Techniques for Measuring Nuclear Morphology and Detecting Dysplasia
ByYizheng Zhu, Francisco E. Robles, Neil G. Terry, Adam Wax
Pages 30

Elastically scattered light from biological media carries ample information about the subject that can be used for biomedical applications such as the study of cell morphology and the assessment of tissue health [1-5]. e dependence of the scattered eld distribution on wavelength, angle, and polarization has been used to extract structural information such as the size of nuclei and organelles, as well as optical properties such as the refractive index and absorption spectrum of the scatterer [6-8]. Such quantitative light scattering information can be obtained by the analysis of either singly scattered photons (e.g., light scattering spectroscopy [LSS]) [1,9] or multiply scattered photons (e.g., elastic scattering spectroscopy) [3,4] and has been shown to be eective for the diagnosis of dysplasia, a precancerous state typically found in the epithelial layer of tissue where the majority of human cancers originate [1].