chapter  12
118 Pages

Chapter 12

ByNachman Brautbar, John A. Williams, II, Michael P. Wu

Keck School of Medicine, University of Southern California, Los Angeles, California, U.S.A.

John A. Williams, II, and Michael P. Wu

Nachman Brautbar, M.D., Inc., Los Angeles, California, U.S.A.


In the last 10 to 15 years, the scientific community has recognized that both

environmental and industrial pollution play a role in cardiovascular diseases. In

this chapter, we have addressed topics of public health importance and scientific

interest in the genesis and contribution of cardiotoxicity. We have approached

each chemical, or group of chemicals of interest, from an experimental animal

point of view through the human cardiotoxicity point of view. Much has yet to be

learned; however, the impact of air pollution and some industrial chemicals on

cardiotoxicity is substantial. Like in any aspect of medical toxicology, we have

tried to differentiate between indirect and direct cardiac toxicity; this however, is

not possible in many of the chemicals studied.