chapter  5
20 Pages

Nonhuman Primate Models for Cardiovascular Research

ByYou-Tang Shen, Franco Rossi, Stephen F. Vatner

Most medical advances have been the product of both basic and applied research

and are based mainly on research in animal models. However, there have been

cases where efficacy and toxicity studies in animals failed to predict clinical

outcomes. These differences could be due, in part, to major species differences

between the animal models used and humans. Rodents are the most commonly

used species for cardiovascular research, whereas nonhuman primates, which

have the greatest genetic and physiological similarity to humans, account for less

than 0.3% of animal research in the United States.