chapter  8
18 Pages

DNA adducts as biomarkers of DNA damage in lung cancer

BySuryanarayana V. Vulimiri and John DiGiovanni

I. Lung cancer — incidence, predisposition, and environment ......... 110 II. Cigarette smoke carcinogens ................................................................ 111

III. Metabolic activation of cigarette smoke carcinogens and DNA adduct formation .................................................................................... 111

IV. Role of smoking-related DNA adducts in lung cancer .................... 112 V. Analysis of smoking-related DNA adducts ....................................... 113

VI. DNA adducts as intermediate biomarkers of lung cancer .............. 114 A. Tobacco carcinogen-induced bulky DNA adducts ................... 114 B. Oxidative DNA damage in smokers........................................... 115

VII. Factors affecting DNA adduct levels in smokers.............................. 116 A. Exposure .......................................................................................... 116 B. Smoking status................................................................................ 116 C. Ethnicity ........................................................................................... 117 D. Gender.............................................................................................. 117 E. Metabolic polymorphisms ............................................................ 118 F. DNA repair ...................................................................................... 119 G. Mutagen sensitivity........................................................................ 119

References.............................................................................................................120

Abstract