chapter  30
10 Pages

Modulation of GAP Junctional Communication by “Epigenetic” Toxicants: A Shared Mechanism in Teratogenesis, Carcinogenesis, Atherogenesis, Immunomodulation, Reproductive and Neurotoxicities

ByJames E. Trosko, Chia-Cheng Chang, Brad Upham

I. Introduction .............................................................................................447 II. Disrupted homeostasis as a shared toxicological mechanism

in many disease states ...........................................................................448 III. GAP junctional communication: “where the toxic rubber hits

the road to diseases” ..............................................................................450 IV. GAP junctional intercellular communication: the biological

rosetta stone in toxicology ....................................................................451 Acknowledgments ..............................................................................................452 References.............................................................................................................453

Abstract