Modeling a Protein Environment in an Enzymatic Catalysis: A Case Study of the Chorismate Mutase Reaction

Enzyme reactions are crucial for most biological processes.1-4 The most important properties of enzymes are generally their catalytic power, substrate specificity, and capacity for regulation. Catalytic acceleration by enzymes is typically in the range of 3 to 9 orders of magnitude, and sometimes up to the order of 15, which is far greater

11.1 Introduction: Enzyme Reaction ..................................................................245 11.2 Example: Chorismate Mutase Reaction .....................................................248 11.3 Computational Methods and Modeling ......................................................249