chapter  4
20 Pages

Genomic Approaches in MDS

WithAndrea Pellagatti

The advent of microarray technology in the last decade has revolutionized the investigation of human disease. While previously available technologies allowed to study only one or a few genes at the same time, microarrays are capable of interrogating thousands of genes simultaneously. There are several different types of microarray platforms that vary in the type of probes immobilized on the array and the kind of information that can be derived. For example, gene expression microarrays are designed to measure changes in gene expression at the RNA level, while comparative genomic hybridization (CGH) and single nucleotide polymorphism (SNP) microarrays are used to look for genomic gains and losses and changes in gene copy number at the DNA level.