ABSTRACT

Zafirlukast (proprietary names-Accolate, Vanticon, Accoleit) (4-(5cyclopentyloxycarbonylamino-1-methyl-indol)-3-ylmethyl)-3-methoxy-N-o-toylsulfonylbenzamide) (Fig. 1). is a highly selective and potent competitive antagonist of cysteinyl leukotrienes (LTC4, LTD4, and LTE4) at the cysteinyl leukotriene receptor in human airways (currently designated as CysLT-1).