ABSTRACT
The aim of this chapter is to provide an overview of the multiple mechanisms of particle-induced toxicity leading to a number of diverse disease endpoints. It lays out the notion of dose as it relates to particle effects-the principal pathogenic processes, cellular events, and diseases caused by particles-and then summarizes the toxic mechanisms for a range of common pathogenic particles. Figure 1 provides an overview of those processes and diseases that arise from exposure to a range of particle types.
