chapter  14
23 Pages

Mechanisms and Processes Underlying Toxicological Responses to Particles

WithVicki Stone, Ken Donaldson

The aim of this chapter is to provide an overview of the multiple mechanisms of particle-induced toxicity leading to a number of diverse disease endpoints. It lays out the notion of dose as it relates to particle effects-the principal pathogenic processes, cellular events, and diseases caused by particles-and then summarizes the toxic mechanisms for a range of common pathogenic particles. Figure 1 provides an overview of those processes and diseases that arise from exposure to a range of particle types.