chapter  4
19 Pages

Particulate Carriers for Pulmonary Drug Delivery

WithStephanie Hein, Andreas Henning, Michael Bur

Drug administration by inhalation is well established, but it has mainly been used for locally treating diseases in the lungs, such as asthma or chronic obstructive pulmonary disease (COPD). During the past two decades, though, increasing attention has been paid to using the healthy lung as a convenient route to treat diseases such as diabetes by aerosol delivery of insulin. Pulmonary delivery offers many advantages as a noninvasive method for both local and systemic drug delivery due to the characteristics of the lung. The lung has a large surface area, offers rapid absorption through the thin alveolar epithelium, there is low enzymatic activity, and it affords direct access to the circulation.