ABSTRACT
Nearly half of the world’s population is infected with H. pylori, a bacterium that causes chronic gastritis and peptic ulcer and has been strongly incriminated in the etiology of gastric cancer, the second most common fatal malignancy. Although antibiotics can cure infection, multidrug regimens are required which are expensive, have side effects, and may induce resistance. These drugs are not amenable to widespread use for primary prevention, or even for treatment, of infection in some areas of the world. For these reasons, vaccines are being developed.
