ABSTRACT
This chapter presents classification & mode of action, indications & dermatological uses, formulations/presentation, dosages & suggested regimens, baseline investigations, considerations & monitoring, contraindications, cautions, important drug interactions, adverse effects & their management, use in special situations, and essential patient information of Herpesviruses. Herpesviruses are members of a large family of DNA viruses that cause disease in humans and animals. Foscarnet is inhibitory for all herpesviruses and human immunodeficiency virus and inhibits viral nucleic acid synthesis by interacting directly with viral DNA polymerase or reverse transcriptase. Oral aciclovir may provide modest clinical benefit in preventing subsequent recurrent orolabial herpes. Valaciclovir and famciclovir have been shown to be superior to aciclovir in reducing herpes zoster associated pain and are generally preferred due to their more convenient dosing regimens. Long-term prophylactic therapy with aciclovir or valaciclovir may be considered in patients with frequently recurring, debilitating genital herpes which is impairing the quality of life.
