ABSTRACT
This chapter presents information on classification & mode of action, indications & dermatological uses, formulations/presentation, dosages & suggested regimens, baseline investigations, considerations & monitoring, contraindications, cautions, important drug interactions, adverse effects & their management, and essential patient information of Alitretinoin. Alitretinoin is an endogenously occurring retinoid which is structurally related to vitamin A. The precise mode of action of alitretinoin in chronic hand eczema remains unclear, but retinoids are known to affect multiple processes at a cellular level including proliferation, differentiation and apoptosis. Alitretinoin has been shown to suppress the expression of co-stimulatory molecules on the surface of antigen-presenting cells, which may be of relevance to a therapeutic effect in contact dermatitis. Pharmacists who dispense alitretinoin should be alert to the potential for confusion. Alitretinoin capsules contain soya bean oil. Patch testing should be performed prior to commencing alitretinoin to exclude a significant underlying contact allergy.
