chapter  14
18 Pages

QSAR Studies on Dihydrofolate Reductase Enzyme: From Model to Biological Activity

Abstract .................................................................................................................400 14.1 Introduction ................................................................................................400 14.2 Structure .....................................................................................................401 14.3 QSAR .........................................................................................................408 14.4 QSAR Study on DHFR Inhibitors .............................................................409 14.5 Conclusion .................................................................................................413 Keywords ..............................................................................................................414 References .............................................................................................................414

Dihydrofolate reductase (DHFR) is an enzyme that has a role in the synthesis of tetrahydrofolate and is used as a target for antineoplastic, antiprotozoal, antifungal, and antimicrobial action. The nicotinamide adenine dinucleotide phosphate-dependent reduction of dihydrofolate to tetrahydrofolate by catalysis of DHFR inhibitors plays an essential role in the synthesis of numerous amino acids. In this chapter, a quantitative structure-activity relationship study on dihydroreductase inhibitors is included.