ABSTRACT
Systems with controlled transport of medicines are the extremely demanded [1, 2]. Research of different processes on diffusion of water and medicinal substance in polymer films and opportunities of control of release of medicines became the purpose of this works. As a matrix for the immobilization of drugs used in naturally occurring polysaccharide chitosan, which has a number of valuable properties: non-toxicity, biocompatibility and high physiological activity [3], as well as a drug used aminoglycoside antibiotic series-amikacin, actively applied in the treatment of pyogenic infections of the skin and soft tissue [4]
14.2 EXPERIMENTALS
The main object of investigation was a chitosan (ChT) specimen produced by the company “Bioprogress” (Russia) and obtained by acetic deacetylation of crab chitin (degree of deacetylation ~84%) with Msd = 3,34,000. As the medicinal substance (MS) used an antibiotic amikacin (AM)— quadribasic aminoglycoside, used in the form of salts-sulfate (AMS) and chloride (AMCh). Chemical formulas of objects of research and their symbols used in the text are given in Table (14.1).
