ABSTRACT
GIOVANNI CIZZA, PAOLO PIAGGI, ELIANE A. LUCASSEN, LILIAN DE JONGE, MARY WALTER, MEGAN S. MATTINGLY, HEATHER KALISH, GYORGY CSAKO, AND KRISTINA I. ROTHER, FOR THE SLEEP EXTENSION STUDY GROUP
10.1 INTRODUCTION
Several epidemiological studies have shown that people who report sleeping less than 6.5 h are at greater risk of gaining weight over time [1]. Furthermore, obesity and obstructive sleep apnea (OSA) frequently coexist: about 40% of obese individuals have OSA; conversely approximately 70% of individuals with OSA are obese [2], [3]. Similar to diabetes, OSA frequently goes undiagnosed [4]. Sleep duration and OSA may affect insulin resistance independently of body mass index (BMI) [5]. In addition, OSA is associated with decreased insulin sensitivity in lean, male subjects,
suggesting that OSA per se may induce insulin resistance, independent of adiposity [6]. Several ongoing studies currently listed in Clinical Trials. gov and other similar web sites are addressing the relationship between OSA and glucose metabolism in obese subjects.
