chapter  4
10 Pages

Cyclooxygenase inhibition in atherothrombotic disease

WithOrina Belton, Sarah McClelland, Des Fitzgerald

Introduction Cyclooxygenases are rate-limiting enzymes in the generation of products that exert a broad spectrum of effects in human systems. The enzymes have been the target for the development of inhibitors in the treatment of inflammation and pain, most recently the ‘coxibs’ or cyclooxygenase-2 selective inhibitors. Cyclooxygenases also have potent effects in the cardiovascular system, and their inhibition has both therapeutic and harmful effects in patients with atherothrombosis, heart failure, and other forms of cardiovascular disease.