chapter  6
24 Pages

Risk Factors and the Morphology of Atherosclerotic Carotid Plaque

ByAlessandro Mauriello

It is possible to hypothesize that carotid plaque stability is influenced not only by local but also by systemic factors, the so-called 'major’ atherosclerotic risk factors (cigarette smoking, hypertension, high serum cholesterol and its fractions, low levels of high-density lipoprotein (HDL), diabetes mellitus). 25-38 The different risk factors may influence the local inflammatory response and the histological plaque composition, 17,18,39-41 inducing carotid plaque progression from stable to unstable.