chapter  37
8 Pages

Micro Computed Tomography Marc Kachelrieß

Tomographic imaging started with clinical x-ray computed

tomography (CT) in 1972.1 Since then, CT technology has

advanced significantly and clinical CT became radiology’s

powerhouse. In addition to clinical CT imaging there is an

increasing need for pre-clinical examinations such as scans of

tissue samples, organs or whole animals (in-vitro or in-vivo)

that are used as models to evaluate human diseases and ther-

apies.2 For example non-invasive imaging of mice gains in

importance due to recent advances in mouse genomics and

the production of transgenic mouse models. Longitudinal

studies that use a single animal population can provide inter-

nally consistent long-term data and help to reduce the

number of sacrificed animals and to cut down the costs.