ABSTRACT
The structural development of human skin has been intensely studied and documented, first at the light, then the electron microscopy level (1). These early observations have now been correlated with molecular localization data, primarily using immunohistochemical techniques. The outcome has been an extremely well-defined understanding of structural development in human skin, which underpins the analysis of cutaneous disease. This structural framework can be used to incorporate the flood of new data from species-specific genome projects, expression analyzes using microarrays, and an abundance of functional data from animal models.
