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Multiple sclerosis (MS) is a progressive disease. It is characterized by initial destruction of myelin and eventually axons and cell bodies. It can affect any part of the central nervous system (CNS). It is well established that MS is a painful condition. There are varying reports of the incidence of pain such as:

• 40% of MS patients are never pain-free. • 64% report pain at some time of their disease. • 48% have more than one pain. • 32% of pain sufferers with MS rate pain amongst the most severe symptoms of their

disease. • Prevalence of pain for the preceding month has been quoted at 53%.