Osteopontin Reduces Biofi lm Formation in a Multi-Species Model of Dental Biofi lm
Bacteria in dental biofilms produce organic acids upon exposure to fermentable dietary carbohydrates. Repeated pH drops at the biofilmtooth interface lead to slow demineralization of the dental hard tissues and the development of carious lesions. The most common and most effective means of caries prevention is the mechanical removal of dental biofilm. However, self-performed mechanical cleaning using both tooth brush and interdental floss does not result in full removal of the biofilm –, and combating the high world-wide prevalence of caries is still one of the major challenges for dental research .