chapter  5
10 Pages

M icrocirculatory C onsequences o f B lood Substitution with H em oglobin Solutions

WithUniversi La Jolla California

It is increasingly apparent that blood substitutes will be based on solutions using some form of modified hemoglobin as an oxygen carrier. This leads to the concept that substitution with “artificial blood” may be viewed as a form of hemodilution with an oxygen-carrying colloid, a process that has a physiologi­ cal basis similar to that of isovolemic colloid hemodilution implemented with dextran or starch, which are non-oxygen-carrying colloids.