chapter  9
14 Pages

Mechanism of Activation of NFKB by Hydrogen Peroxide

WithKirsty G. McPherson, John R. Babson, Anthony J. Kettle, Christine C. Winterbourn

Nuclear transcription factor KB (NFKB) regulates the expression of genes involved in the immune response, acute-phase reaction, and inflammation (1,2). It also induces expression of AIDS virus genes in infected cells. It is normally present in the cytoplasm in an inactive form bound to its inhibitor, IKB. Activation involves phosphorylation and proteolytic degradation of the inhibitor and translocation to the nucleus (1-4). Diverse agents, including tumor necrosis factor-a (TNF-ct) and other cytokines, lipopolysaccharide, phorbol esters, and H2O2 can activate NFKB.