ABSTRACT
Liver cirrhosis occurs in response to chronic liver injury from many causes including alcohol, iron-overload and viruses, for example, hepatitis B (HB) virus, which is often associated with HIV. We describe an HIV-1-seropositive patient with a chronic hepatitis B-related cirrhosis which healed both clinically and histologically under interferon-ct therapy associated with antiretroviral treatment and antioxidant therapy including superoxide dismutase (SOD) and deferoxamine. Indeed, antioxidants seem to have the property of inhibiting viral replication through their action on a cellular transcription factor, the NFKB (1), and SOD was proved efficient in an animal model of radio-induced fibrosis (2).
