chapter  14
22 Pages

Protein Engineering for Biosensors

ByMasuo AU:awa, Yasuko Yanagida, Tetsuya Haruyama and Eiry Kobata.M

A keen interest has been focused on the information networks in biological systems, where information is transduced, transfered, processed, and stored by a molecule or molecular assemblies. The bioinformation networks may be classified into 1) gene information network, 2) intracellular information network, 3) intercellular information network, 4) sensory information network, and 5) brain information network. Of these bioinformation networks, both intracellular and intercellular information networks are characterized by molecular communication in which information molecules such as hormones, cytokines, and cAMP serve as messenger to transfer some specific information from one site to a target. Extensive researches have been concentrated on the mechanisms of information transduction at the target cells. It is generally recognized that molecular information can be transduced by receptor molecular assemblies on the cellular membranes.