chapter  10
26 Pages

Ig-SUPERFAMILY MOLECULES IN NEURAL REGENERATION IN THE CNS

Cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IgSF) are known to be involved in a variety of events during vertebrate nervous system development, including the phenotypic differentiation of specific neurons or glial cells, axon growth and fasciculation, axonal pathfinding, axon-glia and axon-target interactions as well as synapse formation and synapse stabilization (overview in Brümmendorf and Rathjen, 1994). To restore neuronal projections disrupted by a lesion, the many mechanisms required for the establishment of functional connections must be re-activated. Whether and to what extent the repair of lesioned fiber tracts involves the expression or reexpression of IgSF CAMs will be discussed in this chapter.