chapter  4
31 Pages

Ticlopidine and clopidogrel

WithMaurizio Paciaroni, Julien Bogousslavsky, Virgilio Gallai

Atherothrombosis, the common pathogenesis of myocardial infarction, peripheral artery disease and ischemic stroke, may be defined as atherosclerosis with superimposed thrombotic complications (Blecic, 1998; Gent, 1998a; Libby, 1998; Dormandy, 1998; Fuster et al., 1998; Haberl and Dembowski, 1999; Guillot, 1999; Nenci, 1999). In the pathogenesis of atherohrombosis the involvement of platelet activation is critical (Fuster et al., 1992a and 1992b; Ware and Heistad, 1993; Del Zoppo, 1998; Cimminiello and Toschi, 1999; Prentice, 1999). Many clinical trials of secondary prevention after symptomatic artery disease have evaluated the benefit of long-term use of antiplatelet drugs in reducing the risk of subsequent vascular events (Antiplatelet Trialists’ Collaboration, 1988 and 1994).