chapter  2
Skin Metabolism During In Vitro Percutaneous Absorption
ByRobert L. Bronaugh, Margaret E. K. Kraeling, Jeffrey J. Yourick
Pages 6

The skin is a portal of entry and the largest organ of the body. It has been shown to contain the major enzymes found in other tissues of the body (1). Topically applied compounds may be metabolized in skin resulting in altered pharmacologic or toxicologic activity.