The idea of delivering drugs through the skin is as old as human civilization, but the excitement has increased in recent times after the introduction of the ﬁrst transdermal patch in 1970s. Although transdermal route of drug administration offers several advantages such as reduced ﬁrst-pass drug metabolism, no gastro-intestinal degradation, long-term delivery (>24 hours) and control over delivery and termination, only few drug molecules have been formulated into transdermal patches (1). The cause of this imbalance between the beneﬁts of this route and the number of products in the market lies in the skin itself. Skin’s topmost layer, Stratum Corneum (SC), forms a barrier against permeation of xenobiotics into the body and water evaporation out of the body. This barrier must be altered to maximize the advantages of transdermal route of drug administration. This has engaged pharmaceutical scientists, dermatologists, and engineers alike in research over the last couple of decades (2). High research activity in this ﬁeld has led to the introduction of a variety of techniques including formulation-based approaches (3), iontophoresis (4), electroporation (5,6), acoustical methods (7), microneedles (8), jet injection (9), and thermal poration (10).