chapter  1
44 Pages

Mechanisms of Antisense Drug Action, an Introduction

WithStanley T. Crooke, Timothy Vickers, Walt Lima, Hongjiang Wu

The antisense concept derives from an understanding of nucleic acid structure and function and depends on Watson-Crick hybridization [1]. Thus, arguably, the demonstration that nucleic acid hybridization is feasible [2] and the advances in situ hybridization and diagnostic probe technology [3] lay the most basic elements of the foundation supporting the antisense concept.