chapter  1
1 Pages


WithSarah L. Jensen, George T. Nahass

The antiphospholipid antibody syndrome (APS) is a multisystem disorder characterized by persistently elevated antiphospholipid antibodies (APAs) with vascular thrombosis and=or pregnancy morbidity. Anticardiolipin antibodies (ACAs), b2glycoprotein, and the lupus anticoagulant are different classes of APAs associated with this disorder. Various hematologic, neurologic, obstetric, and cutaneous abnormalities are manifest in this syndrome. The chapter reviews the characteristic features of the APS and the various cutaneous manifestations of this syndrome.