REDUCING BACTERIA AND BACTERIAL CHEMICALS IN THE WOUND ENVIRONMENT
The presence of bacteria in and on the superﬁcial soft tissues to the extent that healing progress is delayed or blocked has been described as ‘‘critical colonization’’ (16-18). Traditionally, colonization of a wound has referred to the presence of proliferating bacteria on superﬁcial tissues without injury to or reaction from the host. ‘‘Critical colonization’’ is differentiated from ‘‘noncritical’’ colonization, because it does involve injury to the host. Sibbald et al. (17) have deﬁned critical colonization as a transition point of increased bacterial burden, which occurs when a wound is progressing from superﬁcial colonization towards more invasive local infection.