chapter  3
34 Pages

Animal Models in Cardiology

ByWengen Chen, Henry Gewirtz, Mark Smith, Vasken Dilsizian

Novel clinical SPECT scanners that can acquire projection data without detector heads that rotate around the patient provide an opportunity for fast, dynamic imaging of large animals and would facilitate kinetic modeling for single-photon-emitting tracers. Two such SPECT cameras incorporate solid-state cadmium zinc telluride (CZT) detector components. One device has nine CZT detectors with high-sensitivity parallel hole collimators whose holes are matched to the CZT crystal elements. e detectors swivel to increase sensitivity in the region of the heart (Sharir et  al. 2008, Gambhir et al. 2009). Another device has 19 pinhole cameras focused on the cardiac region (Herzog et al. 2010). Acquisitions with both imaging systems can be performed approximately ve times faster than with conventional gamma cameras. It is likely that new detector technologies will continue to advance cardiac imaging capabilities for single-photon tracers that can be applied to animal as well as human imaging.