ABSTRACT
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1. Characterization: to obtain the functional property parameters for a specic tissue 2. Monitoring: to reveal the evolution of tissue-engineered constructs during in vitro
culture, microscopically or macroscopically and nondestructively 3. Prediction: to establish the correlation of the measurement parameters and the
microstructure
In this chapter, we introduce the principle and suitability of polarization-sensitive optical coherence tomography (PS-OCT), Doppler OCT (D-OCT), and Doppler optical microangiography (DOMAG) to meet the assessment requirements aforementioned. Case studies have been used to demonstrate the alteration of the internal structures of tendon constructs or tissues in response to external conditioning or stimulation, illustrating that this can be revealed by PS-OCT in a quantitative and qualitative manner. e local uid ow and shear stress within three-dimensional porous scaolds can also be mapped by D-OCT. In addition, DOMAG is highlighted as a technique to produce higher resolution images when compared to D-OCT. e two modalities, therefore, can be useful tools for tracking the perfusion behavior within tissue engineering bioreactors.
