ABSTRACT
Permeant ions and voltage change the energy of the blocked state to make it more or less favorable. e amount of binding energy for a simple pore block is described by Equation 14.4:
= − +ln 1
[ ]G k T I Kblocked B D
(14.4)
where ∆Gblocked is the Gibbs free energy for binding kB is the Boltzmann constant T is the absolute temperature ln is a logarithm
Note that binding energy does not saturate at any concentration. is is due to the binding rates of the blocker continuing to increase as concentration is increased.
